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Key words: Famotidine, Nanosuspension, Box-Behnken design, Mucoadhesion, peptic ulcerĪmong various noxious substances such as acid, pepsin, H. Famotidine mucoadhesive nanosuspension could be prepared using the media milling technique and allowing significant reduction in ulcer index compared to famotidine suspension. The in vivo studies on aspirin-induced rats indicated the lowering in ulcer index for famotidine mucoadhesive nanoparticles was 0.46+0.011, which was significantly better than the effect of traditional famotidine suspension (0.66+0.035). Ex-vivo mucoadhesion study showed that famotidine mucoadhesive nanoparticles possessed higher mucoadhesion than the famotidine nanoparticles. The differential scanning calorimetry (DSC) analysis indicated that there was substantial crystallinity change in the nanoparticle compared with the pure drug. The scanning electron microscopy (SEM) showed the nanoparticles as spherical in shape. The optimization was performed using the desirability function and contour plots. A 3-factor, 3-level Box-Behnken design was applied to study the effects of amount of the beads (X 1), PVPK-30(X 2) and Tween-80 (X 3) on the particle size (Y 1), and cumulative percentage drug released after 1h (Y 2). The present study was performed to design and evaluate the famotidine loaded mucoadhesive nanosuspension for aspirin induced ulcer.
IIDepartment of Pharmaceutics Nootan Pharmacy College Visnagar, 384315, Gujarat, India
IDepartment of Pharmaceutics Saraswati Institute of Pharmaceutical Sciences Gandhinagar 382355, Gujarat, India Famotidine mucoadhesive nanosuspension could be prepared using the media milling technique and allowing significant reduction in ulcer index compared to famotidine suspension.įamotidine Nanosuspension Box-Behnken design Mucoadhesion peptic ulcerĭesign and evaluation of famotidine mucoadhesive nanoparticles for aspirin induced ulcer treatmentĭhaval J Patel I, * * Author for correspondence: Jayvadan K Patel II A 3-factor, 3-level Box-Behnken design was applied to study the effects of amount of the beads (X1), PVPK-30(X2) and Tween-80 (X3) on the particle size (Y1), and cumulative percentage drug released after 1h (Y2).